FIG. 1.

Cumulative distance to platform. (A) Morris Water maze learning acquisition performance of all subjects. When learning over days is graphed for all subjects, there is a clear age difference where young rats outperform the aged rats; then by days 4 and 5, a difference begins to emerge between the treatment group and the control aged group. (B) When the highest scoring 40% of rats are examined as the aged impaired (AI) groups for both the control and NT-020 treatment, there is a significant difference between groups on days 5 (one-way analysis of variance [ANOVA] followed by Bonferroni analysis; overall F = 16.55, degrees of freedom [df ] = 2, 12 post hoc for aged control vs. treatment p < 0.05; young vs. NT-020 is not significantly different) and distance to platform (ANOVA, F = 22.6 df = 2, 12, aged control vs. aged NT-020 p < 0.01). (C) Individual rat performance on day 5 of training is shown to demonstrate the wide variance of data within subjects and that there was lower variance in the NT-020-treated group.