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. 2010 Oct;13(5):581–588. doi: 10.1089/rej.2009.1011

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Copyright 2010, Mary Ann Liebert, Inc.

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FIG. 5. — (A) Ki67⁺ cells (cell cycle marker) present in the subventricular zone (SVZ) of young (4-month-old, n = 10) and aged (21-month-old, n = 13) rats counted using stereology. Asterisks denote a significant age-related decline in Ki67-expressing cells, demonstrating a significant increase in number of cells expressing Ki67 staining in the NT-020 treatment group compared with age-matched controls. There is an overall age-related decrease in Ki67⁺ cells in the SVZ with age. (One-way analysis of variance [ANOVA] F = 52.82, degrees of freedom [df ] = 2, 24; followed by Bonferroni post hoc values [***] p < 0.005, [**] p < 0.05). Photomicrographs depicting representative sections of OX6 staining in the granular cell layer (GCL) and subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus (arrows) in young rats (B,C), in control aged rats, (D,E), and NT-020 aged, treated rats (F,G). Scale bars, B, D, F, 100 μm; scale bar, C, E, G, 50 μm. h indicates the hilus of the dentate gyrus.