Dependence of (a) RNO,max on shear stress for different values of the exponent m, and (b) eNOS activation on shear stress, for different dosages of rampmycin in mice. C, control; LD, low dosage; HD, high dosage. Experimental data from ref. (6). AU signifies arbitrary units used by the authors of ref. (6) to quantify eNOS activation. NO, nitric oxide.