Skip to main content
. Author manuscript; available in PMC: 2011 Jan 4.
Published in final edited form as: Biochem J. 2009 Oct 12;423(3):353–361. doi: 10.1042/BJ20090732

Figure 4.

Figure 4

Kinetic data for A6 TCR recognition of the Tax-Y5F4F (panel A) and Tax-Y5F34FF (panel B) peptides presented by HLA-A2. After correction for bulk refractive index shifts, dissociation phases were fit globally to a single exponential decay function to yield koff (gray lines in panels A and B). Panel C shows normalized kinetic data for A6 recognition of the native Tax, Tax-Y5F4F, and Tax-Y5F34FF ligands, highlighting the incremental decreases in dissociation rate with fluorination of position 5. Measured kinetics are reported in Table 2.