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Isothermal calorimetric titrations of the A6 TCR with the Tax-Y5F4F and Tax-Y5F34FF ligands at 4 °C and 37 °C. Thermodynamic parameters are reported in Table 3. At 4 °C, recognition of both peptides is enthalpically opposed and entropically favored, with increasing fluorination resulting in a greater enthalpic penalty. At 37 °C, binding is both enthalpically and entropically driven, yet increasing fluorination again weakens the binding enthalpy change.
