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. Author manuscript; available in PMC: 2011 Jan 4.
Published in final edited form as: Rev Neurol Dis. 2008 Summer;5(3):140–152.

Table 7.

Reports of Antithrombotic Medications for Giant Cell Arteritis

Study Design N Population Intervention Primary Endpoint Outcome
Nesher
et al.37 		Retrospective 166 GCA diagnosed by
biopsy or ACR criteria
between 1980-2000

  1. Prednisone and aspirin (any dose)

  2. Prednisone alone

 Occurrence of a cranial
ischemic complication		 Fewer cranial ischemic
complications with aspirin
(8% vs 29%; P = .01)
Lee
et al.38 		Retrospective 143 GCA diagnosed by
modified ACR criteria
between 1989-2004

  1. Prednisone and aspirin, clopidogrel or warfarin

  2. Prednisone alone

 Occurrence of an
ischemic event;
occurrence of
bleeding complications		 Fewer ischemic events
with aspirin (OR = 0.18;
P < .0005) or warfarin
(OR = 0.17; P < .04);
no observed increase in
bleeding complications

ACR, American College of Rheumatology; GCA, giant cell arteritis; OR, odds ratio.