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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Gene Ther. 2010 Mar 18;17(7):815–826. doi: 10.1038/gt.2010.29

Figure 5. Temporal analysis of cone photoreceptor densities in the Rpe65−/−::Rho−/− mouse retina.

Figure 5

PNA staining (a, b) revealed that cone photoreceptors were abundant in the central and peripheral regions of the untreated, P14 Rpe65−/−::Rho−/− mouse retina, a pattern similar to that seen in the P14, wild type mouse retina (see Fig 1a, b). Cones degenerate in the Rpe65−/−::Rho−/−retina by 5 weeks of age (c), remaining only in the dorsal and temporal retina. D: dorsal; V: ventral; T: temporal; N: nasal. DKO: Rpe65−/−::Rho−/− double knockout mouse. Scale bars (a, c) = 500 μM. Scale bar (b) = 100 μM.