Table 3.

Overview significant changes and trends after gold instillation

	Local pulmonary effects						Systemic effects
	Inflammatory cells			Cytokines		Cell damage	Acute phase proteins
	Cells	Macrophages	Neutrophils	IL-6	TNF-α	ALP	Fibrinogen	CRP
50 nm single	-	-	↑	-	-	-	-	↑*
250 nm single	-	-	↑*	↑	↑	-	↑*	↑*
50 nm agg	-	-	↑	-	↑	↑*	↑*	↑*
250 nm agg	↑	↑	-	-	-	-	-	↑*
quartz	↑↑*	-	↑↑*	-	-	↑↑*	-	↑*

* indicates a statistically significant effect (P < 0.05).