Table 3.
The adjusted odds ratios for metabolic syndrome, its components, and insulin resistance in relation to tertiles of hsCRP and GGT
| Men, N = 822 | Women, N = 1,097 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tertile of hsCRP | Tertile of GGT | Tertile of hsCRP | Tertile of GGT | |||||||||
| 1st | 2nd | 3rd | 1st | 2nd | 3rd | 1st | 2nd | 3rd | 1st | 2nd | 3rd | |
| Characteristics | <0.360 | 0.360-0.800 | >0.800 mg/L | <29 | 29-54 | >54 IU/L | <0.280 | 0.280-0.650 | >0.650 mg/L | <18 | 18-24 | >24 IU/L |
| Metabolic syndrome | 29 (20.6%) | 49 (34.8%) | 63 (44.7%) | 19 (13.5%) | 51 (36.2%) | 71 (50.4%) | 25 (14.7%) | 47 (27.6%) | 98 (57.6%) | 29 (17.1%) | 54 (31.8%) | 87 (51.2%) |
| OR (95% CI) | 1.00 | 1.69 (1.01-2.80) | 2.13 (1.29-3.52) | 1.00 | 3.26 (1.84-5.78) | 6.11 (3.30-11.3) | 1.00 | 1.54 (0.92-2.60) | 3.08 (1.88-5.06) | 1.00 | 1.70 (1.04-2.79) | 2.67 (1.66-4.30) |
| Obesity | 61 (24.9%) | 72 (29.4%) | 112 (45.7%) | 40 (16.3%) | 88 (35.9%) | 117 (47.8%) | 49 (15.1%) | 103 (31.7%) | 173 (53.2%) | 66 (20.3%) | 107 (32.9%) | 152 (46.8%) |
| OR (95% CI) | 1.00 | 1.16 (0.76-1.76) | 2.21 (1.47-3.32) | 1.00 | 2.65 (1.71-4.12) | 4.75 (2.92-7.72) | 1.00 | 2.15 (1.46-3.18) | 4.04 (2.74-5.97) | 1.00 | 1.60 (1.11-2.32) | 2.17 (1.50-3.12) |
| Raised blood pressure | 186 (31.2%) | 201 (33.7%) | 209 (35.1%) | 184 (30.9%) | 208 (34.9%) | 204 (34.2%) | 220 (30.0%) | 249 (34.0%) | 264 (36.0%) | 236 (32.2%) | 245 (33.4%) | 252 (34.4%) |
| OR (95% CI) | 1.00 | 1.34 (0.88-2.03) | 1.20 (0.78-1.85) | 1.00 | 2.13 (1.38-3.29) | 2.72 (1.67-4.43) | 1.00 | 1.02 (0.71-1.46) | 0.97 (0.66-1.42) | 1.00 | 1.22 (0.85-1.74) | 1.19 (0.82-1.73) |
| Hypertriglyceridemia | 49 (27.7%) | 62 (35.0%) | 66 (37.3%) | 28 (15.8%) | 51 (28.8%) | 98 (55.4%) | 31 (19.4%) | 49 (30.6%) | 80 (50.0%) | 26 (16.3%) | 40 (25.0%) | 94 (58.8%) |
| OR (95% CI) | 1.00 | 1.21 (0.77-1.88) | 1.21 (0.77-1.88) | 1.00 | 2.03 (1.22-3.37) | 5.43 (3.18-9.26) | 1.00 | 1.20 (0.73-1.97) | 1.68 (1.03-2.71) | 1.00 | 1.47 (0.87-2.49) | 3.92 (2.40-6.38) |
| Low HDL cholesterolemia | 10 (15.9%) | 26 (41.3%) | 27 (42.9%) | 23 (33.8) | 24 (38.1%) | 16 (25.4%) | 42 (23.7%) | 55 (31.1%) | 80 (45.2%) | 53 (29.9%) | 59 (33.3%) | 65 (36.7%) |
| OR (95% CI) | 1.00 | 2.85 (1.33-6.12) | 2.79 (1.28-6.07) | 1.00 | 0.94 (0.50-1.76) | 0.76 (0.36-1.64) | 1.00 | 1.29 (0.83-2.00) | 1.95 (1.25-3.02) | 1.00 | 1.12 (0.74-1.69) | 1.17 (0.77-1.79) |
| Impaired fasting glucose | 46 (23.8%) | 70 (36.3%) | 77 (39.9%) | 50 (25.9%) | 62 (32.1%) | 81 (42.0%) | 28 (19.3%) | 38 (26.2%) | 79 (54.5%) | 28 (19.3%) | 46 (31.7%) | 71 (49.0%) |
| OR (95% CI) | 1.00 | 1.73 (1.12-2.67) | 1.82 (1.17-2.82) | 1.00 | 1.54 (0.99-2.40) | 2.81 (1.72-4.59) | 1.00 | 1.12 (0.66-1.90) | 2.24 (1.37-3.66) | 1.00 | 1.55 (0.93-2.59) | 2.36 (1.44-3.88) |
| HOMA-IR ≥2.6† | 12 (11.9%) | 37 (36.6%) | 52 (51.5%) | 18 (17.8%) | 36 (35.6%) | 47 (46.5%) | 23 (13.3%) | 49 (28.3%) | 101 (58.4%) | 18 (10.4%) | 58 (33.5%) | 97 (56.1) |
| OR (95% CI) | 1.00 | 3.40 (1.08-3.73) | 5.14 (2.60-10.1) | 1.00 | 2.01 (1.08-3.73) | 3.00 (1.55-5.82) | 1.00 | 1.78 (1.04-3.04) | 3.51 (2.11-5.86) | 1.00 | 3.13 (1.78-5.49) | 4.99 (2.89-8.64) |
Study subjects were divided into three groups (tertiles) according to hsCRP and GGT levels within sex. OR, odds ratio; CI, confidence interval.
† Insulin resistance was defined as HOMA-IR ≥2.6. Adjusted for age, smoking status, alcohol consumption, uric acid, and estimated glomerular filtration rate.