Table 3.
Association between year 15 serum adiponectin concentrations and year 20 lung function; CARDIA "calendar years".
| Year 15 adiponectin quartiles (Q) | YEAR 20 LUNG FUNCTION PARAMETERS (95% CI) | |
|---|---|---|
| MODEL 1 (n = 2,056) | MODEL 2 (n = 2,056) | |
| Year 20 FVC (ml) ± SE | ||
| Q1 | 3916 ± 24 | 3953 ± 24 |
| Q2 | 3968 ± 25 | 3973 ± 25 |
| Q3 | 4032 ± 23 | 4017 ± 23 |
| Q4 | 3997 ± 26 | 3967 ± 25 |
| Q1 minus Q4 | -82 (-156, -7) | -15 (-90, 61) |
| Slope of ln(adiponectin)* | -75 (-135, -14) | -13 (-75, 49) |
| p for trend = 0.01 | p for trend = 0.67 | |
| Year 20 FEV1 (ml) ± SE | ||
| Q1 | 3101 ± 20 | 3126 ± 20 |
| Q2 | 3124 ± 21 | 3128 ± 20 |
| Q3 | 3171 ± 19 | 3162 ± 19 |
| Q4 | 3138 ± 21 | 3117 ± 21 |
| Q1 minus Q4 | -38 (-99, 24) | 9 (-53, 72) |
| Slope of ln(adiponectin)* | -42 (-92, 8) | 1 (-50, 52) |
| p for trend = 0.09 | p for trend = 0.97 | |
| Year 20 FEV1/FVC (%) ± SE | ||
| Q1 | 79.6 ± 0.3 | 79.5 ± 0.3 |
| Q2 | 79.2 ± 0.3 | 79.2 ± 0.3 |
| Q3 | 79.1 ± 0.2 | 79.1 ± 0.2 |
| Q4 | 78.9 ± 0.3 | 79.0 ± 0.3 |
| Q1 minus Q4 | 0.7 (-0.1, 1.5) | 0.5 (-0.3, 1.4) |
| Slope of ln(adiponectin)* | 0.45 (-0.19, 1.09) | -0.30 (-0.37, 0.96) |
| p for trend = 0.16 | p for trend = 0.37 | |
Note 1: Model 1 was adjusted for race, sex, center, age, age2, amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height2at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
* Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).