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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Biol Psychiatry. 2010 Nov 20;69(3):275–281. doi: 10.1016/j.biopsych.2010.09.032

Figure 3. Stability of cue reactivity and interposed self-administration.

Figure 3

Shown is cue reactivity (CR; boxed-in closed circles) as measured by active lever presses for the vehicle pretreatments. Number of rats tested in CR2, CR3, CR4, and CR5 were 5, 3, 3, and 4, respectively; thus, the 15 rats who met the inclusion criteria (maintaining no less than 50% the number of reinforcements achieved on day 14 for the 2 consecutive days of intermittent self-administration; 2 of 17 rats did not meet criteria) each received one randomly assigned vehicle test. Vehicle testing was not significantly different between CR2-CR5 (F(3,11)=0.37). Each CR session was interposed with 2 days of self-administration (0.1 mg/kg/0.1ml METH; FR5; 3hrs/day). The inactive and active lever presses, as well as number of infusions, are shown for these sessions. Stable self-administration was achieved with this intermittent self-administration protocol; one-way rmANOVA showed no difference in number of active lever presses (F(7,12)=1.86; 2 statistical outliers excluded), inactive lever presses (F(7,12)=1.19; 4 statistical outliers excluded), or infusions (F(7,12)=1.17; 2 statistical outliers excluded) across intermittent self-administration period.