Figure 2.
The ghrelin-induced locomotor stimulation is not affected by an orexin A antagonist (SB334867) or an opiod receptor antagonist (naltrexone). (a) Ghrelin (0.33 mg/kg)-induced locomotor stimulation was not affected by VTA administration of SB334867 (5 µg/side) in mice (F(3,24) = 8.44, P = 0.005) (n = 6–8; **P < 0.01, ***P < 0.001 and n.s. P > 0.05, Tukey's HSD post-hoc test). (b) Ghrelin (0.33 mg/kg)-induced locomotor stimulation was not affected by peripheral administration of naltrexone (1 mg/kg) in mice (F(3,28) = 6.01, P = 0.003) (n = 8; **P < 0.01, ***P < 0.001 and n.s. P > 0.05, Tukey's HSD post-hoc test).