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. 2010 Dec;277(23):4837–4848. doi: 10.1111/j.1742-4658.2010.07900.x

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Journal compilation © 2010 Federation of European Biochemical Societies

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Fig. 1 — The human PI3K-III complex. (A) The various subunits of PI3K-III are indicated. VPS34, VPS15 and Beclin 1 are considered to form a core complex onto which accessory subunits can assemble. HEAT repeats (H), WD40 repeats (WD), Bcl-2 binding domain (BD), zinc fingers (ZF) and coiled-coil domains (CC) are indicated. Note that there exist alternative sequence variants for most of the subunits (not indicated). (B) Distinct PI3K-III subcomplexes regulate autophagosome formation and endosomal traffic.