Fig. 2.

PtdIns3P effectors in cell regulation. Endocytic downregulation of a mitogenic receptor (A), autophagy (B) and cytokinesis (C). PtdIns3P effectors involved in the various processes are shown in red. Rabenosyn-5 and EEA1 mediate membrane fusion in the early endocytic pathway. HRS and EAP45 are subunits of the ESCRT machinery that sorts ubiquitinated mitogenic receptors into the ILVs of multivesicular endosomes. DFCP1 mediates phagophore biogenesis, whereas WIPI2 mediates autophagosome biogenesis. FYVE-CENT facilitates cytokinesis. Microtubules are indicated by dashed green lines.