Table 3.
Proliferation and disappearance rates of CD8+ T cells from in vivo labelling in three elderly subjects
| Subject | Peak enrichment (%/day) | Proliferation rate, P (%/day) | Doubling Time (days) | Disappearance rate, d* (%/day) | Half-life (days) |
|---|---|---|---|---|---|
| O13 | |||||
| Pentamer+ | 0·17 | 0·18 | 385 | 1·26 | 55 |
| CD45RO+ | 0·53 | 0·69 | 100 | 7·75 | 9 |
| CD45RO− | 0·69 | 0·82 | 85 | 8·45 | 8 |
| O4 | |||||
| Pentamer+ | 1·3 | 1·44 | 48 | 1·88 | 37 |
| CD45RO+ | 3·92 | 4·71 | 15 | 8·08 | 9 |
| CD45RO− | 2·76 | 3·26 | 21 | 10·89 | 6 |
| O3 | |||||
| Pentamer+ | 0·19 | 3681 | |||
| CD45RO+ | 1·16 | 601 | |||
| CD45RO− | 2·75 | 251 | |||
Data represent measured peak enrichment (a minimum estimate of proliferation rates) and modelled proliferation (p) and disappearance rate constants (d*).
1
Doubling time is derived from p except for O3, where it is based on the peak enrichment.