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Histamine decreases tumour necrosis factor-α (TNF-α) and interleukin-12 (IL-12) secretion into the cell supernatant. Isolated 6-sulpho LacNAc dendritic cells (slanDC) were stimulated for 6 hr with 10 μm histamine, then 100 ng/ml LPS was added and after 24, 48 and 72 hr the cytokine content in the cell culture supernatant was determined by ELISA (mean and SEM of 11 independent experiments are shown). *P < 0·05; **P < 0·005; ***P < 0·001.
