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. 1974 Feb;53(2):652–655. doi: 10.1172/JCI107600

Augmentation of prolactin secretion by estrogen in hypogonadal women.

S S Yen 1, Y Ehara 1, T M Siler 1
PMCID: PMC301509  PMID: 11344580

Abstract

The effect of estrogen on prolactin (PRL) release and gonadotropin suppression was assessed in six experiments performed on four hypogonadal women. Ethinyl estradiol at a dose of 1 microgram/kg per day induced a significant elevation of serum PRL levels within the 1st wk of treatment. There was a further rise until a plateau was reached in about 3-4 wk to levels of more than 3 times the initial concentration. This was accompanied by a pattern of increased episodic fluctuation. The corresponding serum luteinizing hormone and follicle-stimulating hormone fell progressively during the study period. These data indicate that a positive feedback relationship between estrogen and PRL release exists in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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