Table 3.
Effects of Dietary Administration of Freeze-Dried STRWs and BRBs on NMBA-Induced DNA Adduct Formation in the Esophagus of Fischer 344 Ratsa
| Treatment | pmol O6-meGua/mg DNA | % Inhibition |
|---|---|---|
| NMBA (0.25 mg/kg) | 4.4 ± 0.9 | — |
| NMBA + 5% STRWs | 1.4 ± 0.1b | 68 |
| NMBA + 10% STRWs | 1.9 ± 0.7b | 57 |
| NMBA + 5% BRBs | 1.2 ± 0.3b | 73 |
| NMBA + 10% BRBs | 0.9 ± 0.2b | 80 |
a
Abbreviations are as follows: STRWs, strawberries; BRBs, black raspberries; NMBA, N-nitrosomethylbenzylamine; O6-meGua, O6-methylguanine. Rats were fed 5% or 10% freeze-dried STRWs or BRBs for 14 days and then given a single subcutaneous injection of NMBA at 0.25 mg/kg body weight. The esophageal DNA was isolated and O6-meGua measured as described in Materials and Methods. STRW data are taken from Ref. 31 and BRB data are from Ref. 32.
b
Significantly different from NMBA controls (P < 0.05).