Table 7.

Modulation of iNOS and COX-2 Activities in NMBA-Treated Rat Esophagus by 5% Dietary BRBs^a

NMBA	Diet	Nitriteb (mean ± SE)	PGE2c (mean ± SE)
−	AIN-76A	0.48 ± 0.77	1.27 ± 0.75
+	AIN-76A	5.90 ± 0.90	9.89 ± 2.56
+	AIN-76A + BRBs	4.12 ± 0.68d	4.10 ± 1.05d

^aAbbreviations are as follows: iNOS, inducible nitric oxide synthase; COX-2, cyclooxygenase-2; NMBA, N-nitrosomethylbenzylamine; BRBs, black raspberries; PGE₂, prostaglandin E₂. Data are from Ref. 35.

^biNOS activity is expressed as micromolar concentration of nitrite in esophageal protein.

^cCOX-2 activity is expressed as micrograms of PGE₂ per milligram of esophageal protein.

^dSignificantly lower than in rats treated with NMBA and fed AIN-76A diet (P < 0.05).