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Predicted structure of ARF-GEP100. (A) Schematic representation of putative functional domains and location of cDNA probe sequence in ARF-GEP100. (B) Amino acid sequence alignment of Sec7 domain of ARF-GEP100 (p100) with those of cytohesin 1 (C-1) and BIG1. (C) Alignment of Sec7 domain motif 2 and adjacent sequence from p100, EFA6, ARNO, C-1, yeast Sec7 domain (Sec7), Gea2, and BIG1.
