Table 2.

Summary of all cases analysed in this study

All PrP, tau and Aβ scores were obtained using the scoring scheme shown in Figs. 1, 2, and 3. In case of multiple concurrent PrP patterns, the highest individual score (e.g. granular score 2 and synaptic score 1 = final score 2) was used. No cases with cerebellar Aβ were included in this study. A score 4 for frontal cortex tau was given in cases that clearly exceeded the intensity shown in Fig. 3. One case (sCJD VV) scored 0 for tau and was omitted. All other cases had a tau score of 1 or greater. Cases with a tau score of 4 (exceeding the density shown in Fig. 3) are also shown sCJD MM, MV, VV sporadic CJD with PRNP codon 129 genotype, IPD inherited prion disease