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. 2001 Feb 20;98(5):2425–2430. doi: 10.1073/pnas.041614198

Figure 6.

Figure 6

Model depicting FKBP12 regulation of type I TGF-β receptor signaling. (Left) In FKBP12+/+ cells, TGF-β1 induces gene transcription by SMAD2/3, p38, and ERK MAP kinase leading to induction of p21, SMAD7, PAI-1, and other genes under the influence of TGF-β receptor signaling. (Upper Right) FKBP12−/− cells are partially activated in a ligand-independent manner leading to augmentation of p21, SMAD7, and p38. (Lower Right) TGF-β1 treatment of the FKBP12−/− cells cannot further induce or activate these pathways due to feedback influenced by SMAD7. PAI-1 is basally activated in FKBP12−/− cells and can be further activated by TGF-β1.