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. 2007 Jan-Mar;11(1):142–147.

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© 2007 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits for noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited and is not altered in any way.

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Figure 1. — Genealogy demonstrating 4 generations of stomach cancer, 2 of which carried the CDH1 germline mutation, consistent with hereditary diffuse gastric cancer (HDGC). Thirteen patients had prophylactic gastrectomy, including the proband who underwent successful total laparoscopic gastrectomy. Eighteen patients were identified as having gastric cancer, and 11 of those were identified as carrying the CDH1 tumor suppressor gene mutation. Three patients were identified as carrying the CDH1 tumor suppressor gene mutation but did not have cancer.