Table 1.

Effect of chronic treatment with imipramine, citalopram or zinc on basal level of zinc in extracellular fluid measured in microdialysates by anodic stripping voltammetry

Brain region	Control	Imipramine	Citalopram	Zinc
Prefrontal cortex	0.96 ± 0.061	1.16 ± 0.087	1.32 ± 0.067*	1.35 ± 0.126*
Hippocampus	0.95 ± 0.063	n.d.	1.23 ± 0.039*	1.31 ± 0.084**

Rats were treated with imipramine (20 mg/kg), citalopram (20 mg/kg) or zinc (hydroaspartate, 65 mg/kg) once a day for 14 days. Results are expressed in μM as mean ± SEM of four to five rats per group. ANOVA: F(3,20) = 5.827, P = 0.0063 (prefrontal cortex); F(2,13) = 7.985, P = 0.0008 (hippocampus)

n.d. not determined

* P < 0.05, ** P < 0.01 versus control (Dunnett’s post hoc test)