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. Author manuscript; available in PMC: 2011 Jan 5.
Published in final edited form as: Cell. 2009 Apr 3;137(1):32–45. doi: 10.1016/j.cell.2009.03.023

Figure 2. Vesicular Transport and Intraflagellar Transport.

Figure 2

Accumulating evidence indicates that vesicular transport of ciliary proteins from the trans-Golgi network is critical for proper cilium formation and may be facilitated, at least in part, by the intraflagellar transport (IFT) particle protein IFT20. Furthermore, Rabin8 interacts directly with Bardet-Biedl Syndrome protein BBS1, complexed with the BBSome in the basal body. Rabin8 is required for Rab8 GDP/GTP exchange. Rab8-GTP is proposed to be transported in vesicles to the base of the cilium, where it may dock with the ciliary membrane and/or the IFT complex. Upon targeting to the base of the cilium, ciliary proteins are transported toward the ciliary tip with the kinesin-2 motor in cooperation with IFT complex B proteins (listed on the left; shown in orange). TRAF3IP1/elipsa has been shown to function as an accessory anterograde IFT protein that binds directly with IFT20. Recycling of proteins toward the basal body is mediated by a cytoplasmic dynein and IFT complex A proteins (listed on the right; shown in blue).