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. 2010 Dec 16;67(Pt 1):60–66. doi: 10.1107/S0907444910044732

Figure 5.

Figure 5

The active site of hTS with superposition of ligands. Comparison of the R163K form 3 complexes with the cocrystallized hTS–dUMP–raltitrexed structure (PDB code 1hvy; Phan, Koli et al., 2001 ▶) shows the soaked ligands occupying the same space within the active site as hTS cocrystallized with ligands. The FdUMP binary complex is shown in atom-type colors, dUMP from the ternary inhibitory complex with raltitrexed (PDB code 1hvy) in pink, dUMP in the binary complex in green and the glutathione noncovalent adduct in blue.