. Author manuscript; available in PMC: 2011 Dec 22.

Published in final edited form as: Tetrahedron Lett. 2010 Dec 22;51(51):6748–6752. doi: 10.1016/j.tetlet.2010.10.087

Table 2.

Effect of doubling the catalyst loading from 9 mol % to 18 mol % with benzyl 3,5-bis(benzloxy)-4-bromobenzoate (1)

Entry^a	Time	1:3:4^b	Yield of 3^c
9	15 min × 2	0:1:trace	45
10	30 min, 15 min	0:1:trace	49

18 mol % PdCl₂(dppf)CH₂Cl₂ (added in two equal 9 mol% portions), THF:H₂O (10:1) at 0.051 M, 5 eq. of 2, 3 eq. C₂CO₃, 150 °C.

Isolated yield.

Determined by ¹H NMR integration of the crude mixture.