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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Photochem Photobiol. 2010 Oct 14;86(6):1318–1326. doi: 10.1111/j.1751-1097.2010.00815.x

Figure 5. Inhibitory effect of PFE on UVB-induced formation of cyclobutane primidine dimers and 8-oxo-7,8-dihydro-2′-deoxyguanosine in SKH-1 hairless mice.

Figure 5

Twenty four hours post-UVB irradiation, the animals were sacrificed, skin biopsies were taken and frozen in OCT. Skin sections, 6 μm thick, were cut and processed for immunostaining. Immunohistochemical staining for CPDs [a], and 8-oxodG [c] was performed using appropriate antibodies. Representative pictures are shown. The number of CPD positive cells (b) and 8-oxodG positive cells (d) after immunostaining were counted in five different areas of the sections under a microscope. The numbers of CPD and 8-oxodG positive cells are represented as percent of CPD and 8-oxodG positive cells respectively. The data represents the mean ± SE of 8 mice (#p < 0.001 vs control; *p <0.001 vs. UVB).