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. 2010 Dec 13;4(1):58–73.

Figure 3.

Figure 3

DNA methylation profiles in precancerous conditions and clear cell renal cell carcinomas (RCCs). A. Genome-wide DNA methylation profiles in the non-cancerous renal tissue were significantly correlated with clinicopathological parameters of clear cell RCCs developing in individual patients, and also outcome, indicating that DNA methylation alterations at the precancerous stage may generate more malignant cancers and even determine outcome (ref. 46). B. DNA methylation profiles in the non-cancerous renal tissue (Clusters ANM and BNM,see text) were basically inherited by the corresponding clear cell RCCs developing in individual patients as the DNA methylation profiles of Clusters ATM and BTM, respectively (ref. 46). C. In Cluster BTM, the number of clones showing copy number alterations by array-CGH was significantly correlated with that of DNA hypo- and hypermethylation by BAMCA in the same patient, whereas no such significant correlations were observed in Cluster ATM, suggesting that particular DNA methylation profiles may be closely related to chromosomal instability (unpublished data).