Table 2.
CHGA 3′-UTR common variant C+87T and BP. Effect of the T allele on blood pressure status and valuesa
| Sex | Genotype | |||
|---|---|---|---|---|
| a. CHGA C+87T genotype frequencies and BP status (dichotomized)b | ||||
| High BP, n | Low BP, n | P (2-sided) | ||
| Male | C/C | 156 | 107 | |
| C/T or T/T | 95 | 112 | 0.004 | |
| Female | C/C | 112 | 170 | |
| C/T or T/T | 119 | 148 | 0.262 | |
| b. CHGA C+87T genotype and BP as a continuous traitc | ||||
| SBP (mm Hg) | DBP (mm Hg) | |||
| Male | C/C | 137.2±1.6 | 83.7±1.3 | |
| C/T or T/T | 131.2±1.8 | 77.6±1.5 | ||
| Male ANOVA P value | 0.016 | 0.003 | ||
| Female | C/C | 123.8±1.7 | 71.8±1.2 | |
| C/T or T/T | 126.9±1.7 | 73.8±1.3 | ||
| Female ANOVA P value | 0.206 | 0.272 | ||
Reprinted from Journal of the American College of Cardiology, Vol. 52. Chen Y, Rao F, Rodriguez-Flores JL, et al.: Naturally occurring human genetic variation in the 3′-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion; Pages 1468–1481, Copyright 2008, with permission from Elsevier
ANOVA analysis of variance; BP blood pressure; DBP diastolic blood pressure; SBP systolic blood pressure; UTR untranslated region
aSubjects are grouped by absence (C/C) or presence (T/T or C/T) of the T (minor) allele
bResults evaluated by chi-square test
cAllelic association (presence or absence of the T allele) evaluated by univariate ANOVA