Table 2.

Cyclin E and its role in different types of cancer

Breast cancer	poor disease free survival Poor overall survival High tumor grade High tumor stage Lack of steroid receptors HER - 2/neu expression Ki - 67 expression BRCA1 germline mutations Triple negative breast tumours Basal - type keratins (CK 5/6 or CK17) expression Bone, visceral and in general distant relapse
Ovarian Cancer	Controversial correlation with prognosis Serous, clear cell and poorly differentiated carcinomas Higher tumour grade Late stage disease Patient age more than 60 years old at the time of diagnosis Suboptimal cytoreduction Controversial correlation with lifetime ovulatory cycles (LOC) No correlation with the chemotherapy response Marker of aggressive disease in patients with metastatic ovarian carcinoma (low molecular weight isoforms)
Gastric cancer	Promotion of the progression of early gastric cancer Prediction of the survival in early - onset gastric cancer (LMW isoforms) Poor histological grade Serosa invasion Advanced stage Tumour size (p > 0.05) Lymphatic invasion CDK - 2 expression pRb expression
Colorectal carcinomas	Increased risk of recurrence Worse outcome Possible prognostic marker in non metastatic colon cancer Correlation with p21 waf1/cip1 and cell proliferation Blood vessel invasion Gross configuration of the tumour Independent prognostic factor in rectal carcinoma at stage I - III
Melanomas	Histological type Tumour stage Significant association with some specific tumour subtypes
Non small cell lung carcinoma	Poorer survival among stage I to IIIa Invasion of local structures Poor prognosis Ki - 67 labeling index Distant metastases