Table 3.

Copper reservoir in skin layers versus original levels from 0.68% aq. GHK-Cu at 48 h

Skin compartment	Cu at 0 h (μg/cm2)	Cu at 48 h (μg/cm2)	Increase vs. 0 h
Isolated SC (Exp. A)	0.68 ± 0.28; n = 3	290 ± 69; n = 3	438×
Isolated Epi (Exp. B)	0.37 ± 0.17; n = 3	61.1 ± 7.0; n = 3	165×
Dermatomed skin (Exp. C)	1.72 ± 0.47; n = 8	53 ± 8.1; n = 8	31×
Separated epidermisa	0.37 ± 0.7; n = 8	66.7 ± 7.89; n = 8	180×
Separated dermisb	1.72 ± 0.27; n = 8	27.63 ± 8.83; n = 8	16×

^aSeparated following split thickness diffusion; total epidermis

^bDermis separated from split thickness skin following the diffusion experiment