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Fork regression model for bypass of leading-strand damage . In this model, leading-strand replication encounters a blocking lesion (solid rectangle) while lagging-strand replication proceeds past the site of the lesion. Replication fork regression leads to an accurate template for extension of the blocked leading-strand product, and re-advancing the fork (reversing the regression) puts the newly synthesized segment of leading-strand product (blue line) opposite the blocking lesion.
