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. 2011 Jan 5;6(1):e15926. doi: 10.1371/journal.pone.0015926

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Schuijt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Thrombin generation was initiated in human pooled normal plasma with 1 pM tissue factor (TF) in the presence of rP8 (orange), rP19 (green) or rP23 (red) and thrombin generation was measured using a fluorogenic substrate. (B) Lagtime, (C) time to peak (ttpeak) and (D) Endogenous Thrombin Potential (ETP) were measured. Unpaired t-test was used to determine statistical significance. Representatives of three experiments are shown. Results described represent the mean ± SEM.