Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Dec 16;6:93. doi: 10.1186/1744-8069-6-93

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2010 Ren and Neugebauer; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Blockade of mGluR5 inhibits excitatory and inhibitory transmission under normal conditions and in arthritis. (A) A selective mGluR5 antagonist (MTEP, 1 μM) decreased I/O functions of excitatory transmission in slices from normal rats significantly (n = 5 neurons, P < 0.01, two-way ANOVA; see Results). (B) MTEP inhibited EPSCs in slices from arthritic rats significantly (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). (C) Normalized effects (to predrug; set to 1.0) of MTEP on EPSCs were not significantly between arthritis and normal conditions (P > 0.05, unpaired t-test). (D) MTEP decreased I/O functions of inhibitory synaptic transmission in slices from normal animals (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). (E) MTEP decreased IPSCs in slices from arthritic rats significantly (n = 5 neurons, P < 0.01, two-way ANOVA; see Results). (F) Normalized effects (to predrug; set to 1.0) of MTEP on IPSCs were not significantly different between normal and arthritis conditions (P > 0.05, unpaired t-test). (A-F) Symbols and error bars represent means ± SE.