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. 2011 Jan 5;6(1):e15835. doi: 10.1371/journal.pone.0015835

Figure 3. MIV-150 does not accumulate systemically after repeated application.

Figure 3

Animals were treated with 50 µM MIV-150 (PC-815) or 50 µM MIV-150/14 mM zinc acetate dihydrate (PC-1005) daily for 2 weeks (daily) or with 50 µM MIV-150/14 mM zinc acetate dihydrate every other day for 4 weeks (EOD). (A) Plasma and vaginal swabs and (B) cervical and vaginal tissues were collected 8 or 24 h after the last gel and the levels of MIV-150 measured by RIA. The mean concentrations (±SEM, n = 6) of MIV-150 for each treatment group are shown.