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. 2011 Jan 5;6(1):e15844. doi: 10.1371/journal.pone.0015844

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Deleyrolle et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a): Numerical simulation of stem/progenitor cells growth. As the number of stem cells (i.e. LTP cells) generated in a clonally derived sphere is increased, the overall fold expansion and the slope of the growth curve are increased as well. (b): If the numbers of stem (LTP) cells within a sphere is kept constant and the total number of cells within a sphere is doubled (ii) or quadrupled (iii), neither the fold expansion nor the slope of the growth curve are changed however the curve is elevated. LTP, long-term proliferating cells; STP, short-term proliferating cells; ND, non-dividing cells.