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Initial screening of some diterpenoid alkaloids (DAs) for their inhibitory activity towards MK5. The percent inhibition of MK5 kinase activity by compounds 1, 3, 4, 6, 8, 11, and 13 at concentration of 2 mM was tested. The activity of MK5 towards the PRAKtide substrate in the absence of inhibitor was arbitrary set as 100% and the residual activity in the presence of inhibitor was related to this. These values then allowed us to calculate the percentage of inhibition
