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. 2011 Jan;178(1):273–283. doi: 10.1016/j.ajpath.2010.11.027

Figure 1.

Figure 1

Pre-onset accumulation of calcium in dystrophin-deficient skeletal muscle suggests early implication of calcium dysregulation in DMD pathology. A: Calcium uptake (Alizarin Red positive fibers, red) in skeletal muscle from a fetus (13 weeks old) with DMD, compared with skeletal muscle from a control fetus (15 weeks old), which shows no uptake. B: Calcium uptake in tibialis anterior (TA) of C57/BL10-mdx (mdx) mice was not detectable until postnatal week 3. Central nuclei were detectable in both C57/BL10 control (BL/10) and mdx skeletal muscle (TA), confirming ongoing muscle development at this stage. Insets correspond to the higher-magnification image to the left. Scale bars = 100 μm.