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. Author manuscript; available in PMC: 2011 Jan 6.
Published in final edited form as: Pharm Res. 2010 May 19;28(1):41–57. doi: 10.1007/s11095-010-0169-8

Fig. 2.

Fig. 2

Diagrammatic representation of the steps involved in preparation of laser-engineered MN arrays. A Teflon® slab is attached to an aluminium stub using cyanoacrylate glue (A). Silicone is added to the mould and centrifuged at 3,500 rpm for 15 min (B). After curing overnight, the contents of the aluminium container are removed by pressing a metal rod against the aluminium stub (C). Silicone mould is carefully peeled away from the aluminium stub (D). A laser-engineered silicone sheet is attached to the bottom of the silicone mould using cyanoacrylate adhesive (E). Aqueous polymer gel is transferred to the silicone mould (F). The mould is centrifuged, and upon hardening, the silicone mould is carefully peeled away from the MN array (G). Side-walls of MN arrays were cut-off by means of a hot scalpel blade (H).