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. 2010 Oct 13;30(41):13867–13872. doi: 10.1523/JNEUROSCI.2783-10.2010

Figure 1.

Figure 1.

Maintained spatial memory in the Y-maze for aged 11β-HSD1+/− and 11β-HSD1−/− mice but not aged C57BL/6J controls. A, Both young (6 months young; n = 6–8/genotype) and aged (24 months aged; n = 7–8/genotype) mice of C57BL/6J (CON) controls, 11β-HSD1+/− (KO+/−), and 11β-HSD1−/− (KO−/−) mice were able to perform the immediate version of the Y-maze with the 1 min ITI. B, Young mice of all three genotypes show intact spatial memory (with 2 h ITI) spending more time in the novel arm than the other two arms. Aged C57BL/6J (but not aged 11β-HSD1+/− and aged 11β-HSD1−/−) mice show impaired spatial memory with 2 h ITI. Values are means ± SEM. *p < 0.05 compared to novel arm. § p < 0.01 compared to novel arm of aged C57BL/6J mice.