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. Author manuscript; available in PMC: 2011 Jan 6.
Published in final edited form as: Cancer Res. 2007 Jul 1;67(13):6484–6492. doi: 10.1158/0008-5472.CAN-06-4531

Table 2.

Differentially expressed genes in the esophagus of rats treated with NMBA, PEITC, or NMBA + PEITC and associated with phase I and phase II metabolizing enzymes “1”

Unigene Reporter name Gene symbol Sequence description NCBI gene ID Accession NMBA FC PEITC FC NMBA + PEITC FC
Phase I–related genes
A_44_P117389 Cyp2a2 Rat hepatic steroid hydroxylase IIA2 (CYP2A2) gene, exons 1 and 2 24895 M33313 1.94 −1.22 −1.35
 Rn.10489 A_44_P1037342 Cyp3a13 Rattus norvegicus cytochrome P450, family 3, subfamily a, polypeptide 13 171352 NM_147206 2.12 1.14 1.11
Phase II–related genes
 Rn.1916 A_42_P522857 221670_Rn Expressed sequence tags, moderately similar to GST3_human microsomal glutathione S-transferase 3 (Homo sapiens) 289197 BF282898 −3.70 1.14 1.07
A_42_P531078 384436_Rn R. rattus mRNA for glutathione transferase subunit 8 X62660.1 −3.25 1.00 −1.32
 Rn.129343 A_43_P23287 BF566100 Expressed sequence tags, weakly similar to glutathione S-transferase YC-2 (Rattus norvegicus) 363205 BF566100 −10.03 −1.29 1.01
 Rn.2460 A_44_P1011898 Gclm Glutamate-cysteine ligase, modifier subunit 29739 NM_017305 −2.04 1.24 −1.31
A_44_P491831 Gst Glutathione S-transferase Yc2 subunit (rats, fetal liver, mRNA, 1,129 nt) S72506 −1.91 1.73 1.22
 Rn.1692 A_44_P254767 Gss Rattus norvegicus glutathione synthetase, mRNA 25458 NM_012962 1.66 1.04 −1.03
 Rn.109452 A_44_P369808 GST13-13 Rattus norvegicus glutathione S-transferase, mitochondrial, mRNA 297029 NM_181371 −1.66 1.03 −1.05
 Rn.10460 A_42_P624195 Gsta1 Glutathione-S-transferase, α type (Ya) 24421 NM_031509 −2.68 2.02 1.51
 Rn.40574 A_43_P13967 Gsta2 Glutathione-S-transferase, α type (Yc?) 24422 NM_017013 −3.54 1.99 1.97
 Rn.40574 A_44_P109608 Gsta2 Glutathione-S-transferase, α type (Yc?) 24422 NM_017013 −2.35 1.70 1.57
 Rn.87212 A_44_P547801 Gstt2 Glutathione S-transferase, θ2 29487 NM_012796 −1.99 1.03 1.07
 Rn.87212 A_44_P182008 Gstt2 Glutathione S-transferase, θ2 29487 AA998545 −1.64 −1.00 1.06
 Rn.3561 A_43_P12569 Idh1 Isocitrate dehydrogenase 1, soluble 24479 NM_031510 −1.79 −1.03 −1.47
 Rn.1916 A_44_P269544 LOC289197 Rattus norvegicus similar to microsomal glutathione S-transferase 3 (LOC289197), mRNA 289197 XM_213943 −4.47 1.05 1.09
 Rn.127912 A_44_P227286 LOC314570 Rattus norvegicus similar to glutathione S-transferase 8 (GST8-8; chain 8; GST class-α; LOC314570) 314570 XM_234810 −2.89 1.09 −1.25
 Rn.112146 A_44_P380218 LOC366653 Rattus norvegicus similar to glutathione S-transferase 8 (GST8-8; chain 8; GST class-α; LOC366653) 366653 XM_345684 −3.99 1.01 −1.27
 Rn.2580 A_44_P283561 Mgst1 Rattus norvegicus microsomal glutathione S-transferase 1 171341 NM_134349 −1.54 1.28 −1.09
A_44_P609586 TC516234 GST3_human microsomal glutathione S-transferase 3 (microsomal GST-III). (Homo sapiens), partial (80%) −4.37 1.14 1.02