Table 3.
Representative complete blood count and serum chemistry parameters in rhesus macaques after rAAV5RhEPO gene transfera
| Day –21 | Day 1 | Day 7 | Day 56 | Day 112 | Day 182 | |
|---|---|---|---|---|---|---|
| WBC | 16.5 ± 3.9 | 7.1 ± 0.5 | 14.8 ± 10.8 | 13.3 ± 5.6 | 11.7 ± 4.6 | 6.7 ± 1.7 |
| RBC | 4.9 ± 0.2 | 5.1 ± 0.3 | 4.9 ± 0.2 | 5.2 ± 0.1 | 5.1 ± 0.1 | 5.1 ± 0.2 |
| HGB | 12.2 ± 0.1 | 12.6 ± 0.3 | 12.1 ± 0.1 | 13.3 ± 0.1 | 12.6 ± 0.2 | 12.5 ± 0.2 |
| HCT | 36.5 ± 0.6 | 37.5 ± 1.2 | 36.5 ± 0.6 | 38.9 ± 0.5 | 38.0 ± 0.1 | 37.8 ± 0.7 |
| PLAT | 406.3 ± 23.8 | 407.7 ± 33.5 | 431.7 ± 27.8 | 442.0 ± 28.3 | 417.0 ± 20.3 | 396.3 ± 15.9 |
| SEGS | 72.1 ± 10.2 | 63.1 ± 10.9 | 68.0 ± 15.2 | 60.9 ± 11.1 | 62.3 ± 13.5 | 44.4 ± 10.7 |
| LYMPHS | 24.1 ± 14.0 | 33.2 ± 9.9 | 28.2 ± 13.2 | 32.9 ± 10.2 | 31.2 ± 11.4 | 49.3 ± 8.8 |
| Na+ | 148.3 ± 0.3 | 155.7 ± 1.5 | 156.3 ± 0.7 | 154.0 ± 1.0 | 146.7 ± 0.3 | 143.0 ± 0.6 |
| Creatinine | 0.8 ± 0.07 | 0.9 ± 0.03 | 0.9 ± 0.07 | 0.9 ± 0.06 | 0.8 ± 0.06 | 0.9 ± 0.09 |
| SGOT | 57.3 ± 4.3 | 49.7 ± 4.9 | 36.7 ± 4.8 | 49.3 ± 5.5 | 38.0 ± 3.5 | 30.0 ± 2.5 |
| ALP | 710.3 ± 47.4 | 604.0 ± 49.5 | 481.0 ± 32.3 | 511.7 ± 34.7 | 534.3 ± 62.9 | 524.7 ± 80.4 |
| LDH | 710.3 ± 47.4 | 604.0 ± 49.5 | 481.0 ± 32.3 | 511.7 ± 34.7 | 534.3 ± 62.9 | 524.7 ± 80.4 |
| Albumin | 3.9 ± 0.3 | 4.4 ± 0.2 | 4.2 ± 0.1 | 4.5 ± 0.1 | 3.9 ± 0.1 | 3.8 ± 0.1 |
| CPK | 62.0 ± 12.0 | 213.3 ± 17.4 | 161.7 ± 22.4 | 170.0 ± 40.3 | 97.7 ± 35.0 | 88.3 ± 19.2 |
Abbreviations: WBC, white blood cell count as cells mm−3; RBC, red blood cell count as million cells mm−3; HGB, hemoglobin as g per 100 ml; HCT, hematocrit; PLAT, platelet count as × 103 mm−3; SEGS, segmented neutrophils as percent; LYMPHS, lymphocytes as percent; sodium as mEq l−1; creatinine as mg per 100 ml; SGOT, serum glutamic oxaloacetic transaminase as U l−1; ALP (alkaline phosphatase) as U l−1; LDH, lactate dehydrogenase as mg per 100 ml; albumin as g per 100 ml; CPK, creatine phosphokinase as U l−1.
Only the mean ± s.e. of the animals that belong to the high-dose group are presented (n = 3; 3 × 1011 particles directly administered to the right parotid gland).