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. 2010 Nov 9;20(3):445–454. doi: 10.1093/hmg/ddq491

Figure 1.

Figure 1.

Tsc2GFAP1CKO mice have more severe epilepsy and earlier premature death than Tsc1GFAP1CKO mice. (A) Tsc1GFAP1CKO and Tsc2GFAP1CKO mice underwent video-EEG monitoring starting at 3 weeks of age. The EEG tracings show a typical electrographic seizure from a Tsc2GFAP1CKO mice, typically characterized behaviorally by head nodding, rearing, and repetitive forelimb clonus. LFand RF, left and right frontal epidural electrodes. Seizures occur in Tsc2GFAP1CKO mice at 3 weeks and become progressively more frequent with age. Note that no Tsc2GFAP1CKO mice survived long enough in the video-EEG studies to collect seizure frequency data at 8 weeks. In contrast, in Tsc1GFAP1CKO mice, seizures do not start until at least 4 weeks of life and the seizure frequency is significantly lower than in Tsc2GFAP1CKO mice (*P< 0.05, ***P< 0.001 by ANOVA, n= 16 for Tsc2GFAP1CKO and n= 22 for Tsc1GFAP1CKO mice). (B) Both Tsc1GFAP1CKO and Tsc2GFAP1CKO mice exhibit premature death, but Tsc2GFAP1CKO die earlier than Tsc1GFAP1CKO mice (P< 0.05 by the Kaplan–Meier log-rank test, n= 18 for Tsc2GFAP1CKO and n= 25 for Tsc1GFAP1CKO mice).