Skip to main content
. 2010 Nov 9;20(3):445–454. doi: 10.1093/hmg/ddq491

Figure 3.

Figure 3.

Tsc2GFAP1CKO mice have more severe neuronal disorganization and megencephaly than Tsc1GFAP1CKO mice. (A) Cresyl violet staining demonstrated an obvious dispersion of the pyramidal cell layer in hippocampus of both Tsc1GFAP1CKO and Tsc2GFAP1CKO compared with controls, but this was more pronounced in Tsc2GFAP1CKO mice. Scale bars = 200 µm and 100 µm for low- and high-power images, respectively. (B) Brain weight was significantly increased in both Tsc1GFAP1CKO and Tsc2GFAP1CKO mice compared with controls starting at 3 weeks of age, and was greater in Tsc2GFAP1CKO mice compared with Tsc1GFAP1CKO mice starting at 5 weeks of age (**P< 0.01, ***P< 0.001 by ANOVA, n= 6 mice per group).