Table 2.
Proteins in the MD subnetwork and other ataxin-7 interactors
| Human symbol | Entrez ID | Mouse symbol | Entrez ID | Expression studies | Human mapped loc. | Overlapping RetNet unmapped? |
|---|---|---|---|---|---|---|
| ACTN1a | 87 | Actn1 | 109711 | Blackshaw et al. (65) | 14q22–q24 | No |
| ACTN2 | 88 | Actn2 | 11472 | Schulz et al. (72) | 1q42–q43 | No |
| ACTN4 | 81 | Actn4 | 60595 | Schulz et al. (72) | 19q13 | MCDR5 |
| ADAM33 | 80332 | Adam33 | 110751 | UniGene Hs.173716 | 20p13 | No |
| AGRNa | 375790 | Agrn | 11603 | Blackshaw et al. (65) | 1p36.33 | LCA9 |
| ATN1a | 1822 | Atn1 | 13498 | Blackshaw et al. (65), Zhang et al. (71) | 12p13.31 | No |
| ATXN1La | 342371 | Atxn1L | 52335 | Blackshaw et al. (65) | 16q22.2 | No-FHASD close |
| ATXN7a | 6314 | Atxn7 | 246103 | Ström et al. (70) and this study | 3p21.1–p12 | Yes-itself |
| CACNA1Aa | 773 | Cacna1a | 12286 | Xu et al. (87) and Blackshaw et al. (65) | 19p13.2–p13.1 | No |
| CARD10 | 29775 | Card10 | 105844 | Schulz et al. (72) | 22q13.1 | OPA5 and VRD1 |
| CEP70 | 80321 | Cep70 | 68121 | Blackshaw et al. (65) | 3q22–q23 | No |
| CEP72 | 55722 | Cep72 | 74470 | Blackshaw et al. (65) | 5p15.33 | MCDR3 |
| COG6 | 57511 | Cog6 | 67542 | Blackshaw et al. (65) | 13q13.3 | No |
| CRIM1a | 51232 | Crim1 | 50766 | Lovicu et al. (78), Kinna et al. (98), Pennisi et al. (81) | 2p21 | No |
| EFEMP1a | 2202 | Efemp1 | 216616 | Stone et al. (84) | 2p16 | No |
| EFEMP2a | 30008 | Efemp2 | 58859 | Blackshaw et al. (65) | 11q13 | VRNI |
| FBLN5a | 10516 | Fbln5 | 23876 | Blackshaw et al. (65) | 14q32.1 | ACHM1 and itself |
| FBN1 | 2200 | Fbn1 | 14118 | Blackshaw et al. (65) | 15q21.1 | No |
| FN1 | 2335 | Fn1 | 14268 | Blackshaw et al. (65), Siegert et al. (83) | 2q34 | No |
| GFI1Ba | 8328 | Gfi1b | 14582 | This study | 9q34.13 | No |
| GOLGA2 | 2801 | Golga2 | 99412 | Blackshaw et al. (65) | 9q34.11 | No |
| GOLGA3 | 2802 | Golga3 | 269682 | Blackshaw et al. (65) | 12q24.33 | No |
| GPRASP1 | 9737 | Gprasp1 | 67298 | Blackshaw et al. (65) | Xq22.1 | No |
| GRNa | 2896 | Grn | 14824 | Blackshaw et al. (65) | 17q21.32 | CORD4 |
| JAG2a | 3714 | Jag2 | 16450 | Blackshaw et al. (65) | 14q32 | ACHM1 |
| KALRNa | 8997 | Kalrn | 545156 | Unigene Hs.8004 | 3q21.1–q21.2 | No |
| LAMB1a | 3912 | Lamb1-1 | 16777 | Sarthy and Fu (68) | 7q22 | No |
| LAMB2 | 3913 | Lamb2 | 16779 | Blackshaw et al. (65) | 3p21 | No |
| LRSAM1 | 90678 | Lrsam1 | 227738 | Blackshaw et al. (65) | 9q33.3–q34.11 | No |
| LTBP4a | 8425 | Ltbp4 | 108075 | Blackshaw et al. (65) | 19q13.1–q13.2 | No-MCDR5 close |
| MATN2a | 4147 | Matn2 | 17181 | Fuchshofer et al. (75) | 8q22 | OPA6 |
| MEGF6a | 1953 | Megf6 | 230971 | Blackshaw et al. (65) | 1p36.3 | LCA9 |
| MEGF8a | 1954 | Megf8 | 269878 | Blackshaw et al. (65) | 19q12 | No |
| MPRIP | 23164 | Mprip | 26936 | Blackshaw et al. (65) | 17p11.2 | No |
| NELL1a | 4745 | Nell1 | 338352 | Piri et al. (67) | 11p15.2–p15.1 | No |
| NELL2a | 4753 | Nell2 | 54003 | Blackshaw et al. (65) | 12q13.11–q13.12 | No-CODA1 close |
| NOC2La | 26155 | Noc2l | 57741 | Hublitz et al. (66) | 1p36.33 | LCA9 |
| NUP62 | 23636 | Nup62 | 18226 | Blackshaw et al. (65) | 19q13.33 | No-MCDR5 close |
| PICK1a | 9463 | Pick1 | 18693 | Blackshaw et al. (65) | 22q13.1 | OPA5 and VRD1 |
| PNMA1 | 9240 | Pnma1 | 70481 | Schulz et al. (72) | 14q24.3 | ACHM1 |
| PPP1R12Ca | 54776 | Ppp1r12c | 232807 | Schulz et al. (72) | 19q13.42 | No |
| RABEP1 | 9135 | Rabep1 | 54189 | Blackshaw et al. (65) | 17p13.2 | CACD |
| RAD23A | 5886 | Rad23a | 19358 | Blackshaw et al. (65) | 19p13.2 | No |
| REREa | 473 | Rere | 68703 | Blackshaw et al. (65) | 1p36 | LCA9 |
| TRIM27a | 5987 | Trim27 | 19720 | Blackshaw et al. (65) and this study | 6p22 | No |
| RNF31a | 55072 | Rnf31 | 268749 | Schulz et al. (72) | 14q11.2 | MCDR4 |
| SIAH1a | 6477 | Siah1a | 20437 | Schulz et al. (72), Yego and Mohr (89) | 16q12 | No |
| Siah1b | 20438 | |||||
| SNX1 | 6642 | Snx1 | 56440 | Blackshaw et al. (65) | 15q22.31 | No |
| SPRY1a | 10252 | Spry1 | 24063 | Blackshaw et al. (65) | 4q28.1 | No |
| SSFA2 | 6744 | Ssfa2 | 70599 | Blackshaw et al. (65) | 2q31.3 | No |
| THY1 | 7070 | Thy1 | 21838 | Blackshaw et al. (65) | 11q22.3–q23 | No |
| TMEM25a | 84866 | Tmem25 | 71687 | Blackshaw et al. (65) | 11q23.3 | No |
| TP53BP2 | 7159 | Trp53bp2 | 209456 | Blackshaw et al. (65) | 1q42.1 | No |
| TRAF2 | 7186 | Traf2 | 22030 | Blackshaw et al. (65) | 9q34 | No |
| TRIM23 | 373 | Trim23 | 81003 | Blackshaw et al. (65) | 5q12.3 | No |
| TRIM54 | 57159 | Trim54 | 58522 | Blackshaw et al. (65) | 2p23.3 | No |
| TXNDC11a | 51061 | Txndc11 | 106200 | Schulz et al. (72) | 16p13.13 | No |
| UBQLN2 | 29978 | Ubqln2 | 54609 | Blackshaw et al. (65) | Xp11.23–p11.1 | OPA2 |
| VWFa | 7450 | Vwf | 22371 | Blackshaw et al. (65) | 12p13.3 | No |
Entrez IDs and symbols are shown for both human and mice. Expression in the retina is based on the noted reference(s). RetNet (http://www.sph.uth.tmc.edu/retnet/) loci that are overlapping or near (in case of unmatched markers) the chromosomal location of the indicated protein.
aProtein is in the MD subnetwork. The remainder interact with ataxin-7 but are not part of the MD subnetwork.