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. 2011 Jan 1;22(1):105–116. doi: 10.1091/mbc.E10-03-0185

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© 2011 Abreu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Expression of active RhoA reverses the Gab2-associated cellular phenotype. (A) Cytoskeletal organization. Vector control and MCF-10A/Gab2 cells were transfected with constructs encoding either myc-tagged RhoA wt or RhoA Q63L and then allowed to spread for 18 h on collagen IV. Transfected cells were identified by anti-myc staining. F-actin was stained with FITC-phalloidin and FAs with an anti-paxillin antibody. Scale bar is 10 μm. (B) Random cell motility. Control MCF-10A/Gab2 cells, and cells expressing RhoA Q63L, were subject to cell tracking analysis. Graphs indicate effects on cell displacement and speed. † and * indicate p < 0.05 and p < 0.01, respectively.