Table 5.
Distribution of pharmaceutical output related to pediatric needs by therapeutic area and burden of disease in children under 15 years (as measured by disability-adjusted life years and mortality)
| Disease conditions | Pharmaceutical output related to pediatric needs | Burden of disease in children under 15 years | ||||
|---|---|---|---|---|---|---|
| PIPs | NCEs | Mortality per 106 (%) | DALYs per 106 (%) | |||
| Number (%) | Number (%) | Worldwide | EU-25 | Worldwide | EU-25 | |
| Communicable diseases | 20 (19.4) | 19 (20.0) | 10.1 (84.6) | 0.1 (43.7) | 406.5 (74.1) | 0.9 (24.6) |
| Infectious and parasitic diseases | 12 (11.6) | 12 (12.6) | 4.6 (38.6) | .01 (3.4) | 176.5 (32.2) | 0.1 (3.8) |
| Respiratory infections | 5 (4.8) | 4 (4.2) | 2.1 (17.3) | .01 (2.0) | 76.2 (13.9) | .07 (1.9) |
| Maternal conditions | 2 (1.9) | 2 (2.1) | .00 (0.0) | .00 (0.0) | 0.5 (0.1) | .00 (0.0) |
| Perinatal conditions | 1 (1.0) | 1 (1.0) | 3.2 (26.8) | 0.1 (38.3) | 126.4 (23.1) | 0.6 (16.2) |
| Noncommunicable diseases | 83 (80.6) | 76 (80.0) | 1.0 (8.1) | 0.1 (44.3) | 93.5 (17.1) | 2.3 (64.2) |
| Malignant neoplasms | 16 (15.5) | 15 (15.8) | .09 (0.7) | .02 (7.1) | 3.2 (0.6) | .09 (2.4) |
| Other neoplasms | - | - | .01 (0.1) | .00 (0.9) | 0.3 (0.1) | .01 (0.3) |
| Diabetes mellitus | 9 (8.7) | 7 (7.4) | .01 (0.1) | .00 (0.1) | 0.3 (0.1) | .00 (0.1) |
| Blood and endocrine disorders | 15 (14.6) | 14 (14.7) | .05 (0.4) | .01 (3.2) | 3.4 (0.6) | 0.1 (3.8) |
| Neuropsychiatric conditions | 9 (8.7) | 9 (9.5) | .08 (0.6) | .02 (4.8) | 30.6 (5.6) | 0.9 (24.6) |
| Sense organ diseases | 1 (1.0) | 1 (1.0) | .00 (0.0) | .00 (0.0) | 4.5 (0.8) | 0.1 (3.6) |
| Cardiovascular diseases | 12 (11.6) | 11 (11.6) | 0.1 (1.0) | .01 (2.7) | 5.1 (0.9) | .04 (1.1) |
| Respiratory diseases | 4 (3.9) | 4 (4.2) | .06 (0.5) | .00 (1.1) | 9.2 (1.7) | 0.3 (9.0) |
| Digestive diseases | 2 (1.9) | 1 (1.0) | 0.1 (1.1) | .00 (1.0) | 6.5 (1.2) | .05 (1.7) |
| Genitourinary diseases | 2 (1.9) | 2 (2.1) | .03 (0.3) | .00 (0.2) | 1.6 (0.3) | .01 (0.2) |
| Skin diseases | 6 (5.8) | 6 (6.3) | .00 (0.0) | .00 (0.0) | 0.9 (0.2) | .00 (0.1) |
| Musculoskeletal diseases | 7 (6.8) | 6 (6.3) | .00 (0.0) | .00 (0.2) | 1.6 (0.3) | .03 (0.9) |
| Congenital anomalies | - | - | 0.4 (3.3) | .07 (23.1) | 24.1 (4.4) | 0.5 (14.5) |
| Oral conditions | - | - | .00 (0.0) | .00 (0.0) | 2.2 (0.4) | .08 (2.2) |
| Unintentional injuries (poisoning) | - | - | .03 (0.3) | .00 (0.2) | 1.2 (0.2) | .00 (0.1) |
| Total | 103 (100) | 95 (100) | 11.9 (100) | 0.3 (100) | 548.4 (100) | 3.6 (100) |
Data do not sum to 100% because of rounding errors. Burden of disease data are from World Health Organization 2009 for the year 2004. Burden of disease in children under 15 years is measured by mortality and disability-adjusted life years (DALYs). PIPs = Pediatric Investigation Plans. EU-25 = all 25 EU countries in 2004. *NCEs = new chemical entities with an agreed PIP.