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. 2011 Jan 6;6(1):e15861. doi: 10.1371/journal.pone.0015861

Figure 3. Second-site immunization in the presence of PRO 2000 increases systemic and mucosal antibody responses.

Figure 3

BALB/c mice (n = 7) were primed intranasally with 10 µg gp140 per animal in polycation and were boosted three times vaginally with gp140 +/− PRO 2000. Samples were collected 14 days after the final vaginal immunization. Serum IgG endpoint titres (A), or vaginal lavage IgG (B) and IgA (C) endpoint titres normalized to the total IgG or IgA content or each sample, respectively, are displayed. gp140 + PRO, combination of gp140 and PRO 2000.* p<0.05.