Table 2.
Topological properties of BioCarta pathway/process extensions 17
| Property | Proposed extension: Added proteins only (mean) | Random model: Added proteins only (mean/stddev.) | Original cellular processes (mean/stddev.) | All network proteins (mean/stddev.) |
|---|---|---|---|---|
| Shortest path length | 3.68 | 4.11(0.03) | 3.77 (0.51) | 4.12(0.94) |
| Node betweenness | 21998 | 14545(4751) | 49888 (153173) | 14669(68893) |
| Degree | 10.3 | 8.11(0.94) | 21.53 (32.64) | 8.27(16.2) |
| Clustering coefficient | 0.34 | 0.11(0.01) | 0.12 (0.17) | 0.11(0.21) |
| Eigenvector centrality | 0.04 | 0.01(0.04) | 0.05 (0.09) | 0(0.57) |
Comparison of different numerical topological properties for the proteins added by the proposed extension method (column 1) or the random model (column 2), as well as a comparison of these properties for the nodes corresponding to the original cellular processes (column 3) and the entire protein-protein interaction network (column 4).